Borderlands 2 Best Mothers Day Ever is a mission that can be activated in the southern side of the Highlands area, on the hill of Isotope Reclamation Tower (the highest building in the southern/south-western part of the region).
SPOILERS AHEAD!
Near the towers stairs, we can find a gift box with a yellow exclamation mark above it (a small chest with an unusual design).
Picking it up, triggers the Borderlands 2 Best Mothers Day Ever mission, in which we find out that the chest is actually a present for Taggarts mother (the character from Stalker of Stalkers optional mission), and in order to open it, we must pick up the key from Henrys lair.
Description
Youve found a Mothers Day present. Unfortunately, it can only be opened with the fist-print of the man who bought it. If you wanna see whats inside the box, youll have to track down Taggarts fist.
Level: 18
Rewards
Item: Shield
Experience: 3208 XP
Walkthrough
Our first objective in the Borderlands 2 Best Mothers Day Ever mission is to go and find Henrys lair, which is located right near the entrance to the town of Overlook (Hunters Bane). As soon as we enter this region, we willhave to kill six of Henrys minions (Ambush Stalkers). Doing this using our vehicles weapons saves us from some trouble.
After we eliminate six of them, Henry will appear. He is actually a big stalker (roughly the size of our vehicle), but then again, killing him using the same weapons is the best strategy we can adopt. He may regenerate his shield during the fight and he may also spawn more minions.
When he is dead, we grab Taggarts fist from him and then we go to the central rock in this lair (where the waypoint is). Inside, we must place the gift box on the ground and use the fist to open it. This action allows us to instantly complete the Borderlands 2 Best Mothers Day Ever mission, and we will also receive the shield thats inside the chest.